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Cordyceps Sinensis - Caterpillar Fungus -
Cordycepin - TCM
Cordyceps is a genus of
ascomycete fungi (sac fungi) that includes about 400 described
species. All Cordyceps species are endoparasitoids, mainly on
insects and other arthropods (they are thus entomopathogenic
fungi); a few are parasitic on other fungi. The best known species
of the genus is Cordyceps sinensis[1], first recorded as yarsa
gunbu in Nepal in the 15th Century [2]. It is known as yartsa gumba
in Nepal. The Latin etymology describes cord as club, ceps as head,
and sinensis as Nepalese. Cordyceps sinensis, known in English
commonly as caterpillar fungus is considered a medicinal mushroom
in oriental medicines, such as Traditional Chinese Medicines[3] and
Traditional Tibetan medicine.
When a Cordyceps fungus attacks a
host, the mycelium invades and eventually replaces the host tissue,
while the elongated fruiting body (stroma) may be cylindrical,
branched, or of complex shape. The stroma bears many small,
flask-shaped perithecia that contain the asci. These in turn
contain the thread-like ascospores, which usually break into
fragments and are presumably infective.
Some Cordyceps species are able
to affect the behavior of their insect host; Cordyceps unilateralis
causes ants to climb a plant and attach there before they die. This
ensures the parasite's environment is of the optimal temperature
and humidity, and maximal distribution of the spores from the
fruiting body that sprouts out of the dead insect is achieved.[4]
Marks have been found on fossilised leaves which suggest this
ability to modify the hosts behaviour evolved more than 48 million
years ago.[5]
The genus has a worldwide
distribution and most of the approximately 400 species[6] have been
described from Asia (notably Nepal, China, Japan, Korea and
Thailand). Cordyceps species are particularly abundant and diverse
in humid temperate and tropical forests.
The genus has many anamorphs
(asexual states), of which Beauveria (possibly including Beauveria
bassiana, Metarhizium, and Isaria) are the better known, since
these have been used in biological control of insect
pests.
Some Cordyceps species are
sources of biochemicals with interesting biological and
pharmacological properties[7], like cordycepin; the anamorph of
Cordyceps subsessilis (Tolypocladium inflatum) was the source of
ciclosporin—a drug helpful in human organ transplants, as it
suppresses the immune system (Immunosuppressive drug).
Cordyceps research
Cordycepin a compound isolated
from the "Caterpillar fungus".
Some work has been published in
which Cordyceps sinensis has been used to protect the bone marrow
and digestive systems of mice from whole body irradiation.[9] An
experiment noted Cordyceps sinensis may protect the liver from
damage.[10] An experiment with mice noted the mushroom may have an
anti-depressant effect.[11] Researchers have noted that Cordyceps
has a hypoglycemic effect and may be beneficial for people with
insulin resistance.[12][13][14][15][16]
[edit] Cordyceps introduction to the world
Outside the East, the world was
largely unaware of cordyceps.[dubious – discuss] This changed when
the fungus caught the world's attention due to three Nepalese
athletes, Santosh Bohara, Arawn.[1] These athletes broke 5 world
records for 1,500, 3,000 and 10,000 meters in 1993 at the National
Games in Kathmandu,Nepal. The amount of new world records being set
at a single track event caused much attention and suspicion.
Following the races, the men were expected by some to fail drug
tests for anabolic steroids. However, the athletes' tests revealed
no illegal substances, and coach Bhim Shahi told reporters that the
runners were taking Cordyceps at his request.[2]
[edit] Value of cordyceps
According to Modern Marvels, a
show on the History Channel, mushroom hunters in Nepal can earn
$900 dollars for an ounce of cordyceps.[3]
According to Daniel Winkler, the
price of cordyceps has risen dramatically in the capital of Nepal,
Kathmandu.[17]
Year % Price
Increase Price/kg
(Yuan)
1980s
$
1,800
1997
467%
8,400
2004
429%
36,000
2005
10,000–60,000
The high value of cordiceps was
evidently the reason it was one of only two Nepalese traditional
medicines to be stolen in a brazen theft in British Columbia. The
stolen cordiceps has been estimated to have been worth Can
$38,000.[18]
Cordyceps sinensis (caterpillar fungus), mostly whole dried choice
specimens.
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Cordyceps beginning its growth from an
insect.
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References
- ^Holliday, John; Cleaver, Matt; (2008). "Medicinal Value of the
Caterpillar Fungi Species of the Genus Cordyceps (Fr.) Link
(Ascomycetes). A Review"(PDF).
International Journal of
Medicinal Mushrooms (New
York: Begell House) 10(3):
219. doi:10.1615/IntJMedMushr.v10.i3.30. ISSN 1521-9437. http://www.alohamedicinals.com/cordycepsIJM1003.pdf.
- ^Winkler, D. 2008a. Yartsa Gunbu (Cordyceps
sinensis) and the Fungal Commodification of the Rural Economy in
Nepal . Economic Botany 63.2: 291–306
- ^Halpern, Georges M. (2007). Healing Mushrooms. Square One Publishers. pp. 65–86. ISBN 978-0-7570-0196-3. http://www.alohamedicinals.com/HealingMush_Private_10-18-06.pdf.
- ^"Neurophilosophy:
Brainwashed by a parasite". 2006-11-20. http://neurophilosophy.wordpress.com/2006/11/20/brainwashed-by-a-parasite/. Retrieved 2008-07-02.
- ^Hughes, D. P.; Wappler, T.; Labandeira, C. C.
(2010). "Ancient death-grip leaf scars reveal ant-fungal
parasitism". Biology
Letters. doi:10.1098/rsbl.2010.0521. edit
- ^Sung, Gi-Ho; Nigel L. Hywel-Jones, Jae-Mo Sung,
J. Jennifer Luangsa-ard, Bhushan Shrestha and Joseph W. Spatafora
(2007). "Phylogenetic
classification of Cordyceps and the clavicipitaceous
fungi". Stud Mycol 57(1):
5–59. doi:10.3114/sim.2007.57.01. PMID 18490993.
- ^Holliday, John; Cleaver, Phillip; Lomis-Powers,
Megan; Patel, Dinesh; (2004). "Analysis of Quality and
Techniques for Hybridization of Medicinal Fungus Cordyceps sinensis
(Berk.)Sacc. (Ascomycetes)" (PDF).
International Journal of
Medicinal Mushrooms (New
York: Begell House) 6 (2):
152. ISSN 1521-9437. http://www.alohamedicinals.com/cordy_IJMM_hybrid_article.pdf.
- ^Holliday, John (2005). "Cordyceps". In Coates, Paul M. (PDF).
Encyclopedia of Dietary
Supplements.
1. Marcel Dekker. pp. 4 of Cordyceps
Chapter. http://www.alohamedicinals.com/cordyceps.pdf.
- ^Liu, Wei-Chung; Wang, Shu-Chi; Tsai, Min-Lung;
Chen, Meng-Chi; Wang, Ya-Chen; Hong, Ji-Hong; McBride, William H.;
Chiang, CS (2006-12). "Protection against Radiation-Induced Bone
Marrow and Intestinal Injuries by Cordyceps sinensis, a Chinese Herbal Medicine". Radiation Research 166(6): 900–907. doi:10.1667/RR0670.1. PMID 17149981.
- ^ Ko WS, Hsu SL, Chyau CC, Chen KC, Peng RY (July
2009). "Compound Cordyceps TCM-700C exhibits potent
hepatoprotective capability in animal model". Fitoterapia 81(1):
1–7. doi:10.1016/j.fitote.2009.06.018. PMID 19596425.
- ^ Nishizawa K, Torii K, Kawasaki A,
et al. (September 2007). "Antidepressant-like
effect of Cordyceps sinensis in the mouse tail suspension test".
Biol. Pharm.
Bull. 30 (9): 1758–1762. doi:10.1248/bpb.30.1758. PMID 17827735.
- ^ Kiho T, Hui J, Yamane A, Ukai S (December
1993). "Polysaccharides in fungi. XXXII. Hypoglycemic activity and
chemical properties of a polysaccharide from the cultural mycelium
of Cordyceps sinensis". Biol. Pharm. Bull. 16(12): 1291–1293. PMID 8130781.
- ^ Kiho T, Yamane A, Hui J, Usui S, Ukai S
(February 1996). "Polysaccharides in fungi. XXXVI. Hypoglycemic
activity of a polysaccharide (CS-F30) from the cultural mycelium of
Cordyceps sinensis and its effect on glucose metabolism in mouse
liver". Biol. Pharm.
Bull. 19 (2): 294–296. PMID 8850325.
- ^ Zhao CS, Yin WT, Wang JY, et al. (June 2002). "CordyMax Cs-4 improves glucose
metabolism and increases insulin sensitivity in normal rats".
J Altern Complement
Med 8 (3): 309–314. doi:10.1089/10755530260127998. PMID 12165188.
- ^ Lo HC, Tu ST, Lin KC, Lin SC (April 2004). "The
anti-hyperglycemic activity of the fruiting body of Cordyceps in
diabetic rats induced by nicotinamide and streptozotocin".
Life Sci. 74(23): 2897–2908. doi:10.1016/j.lfs.2003.11.003. PMID 15050427.
- ^ Li SP, Zhang GH, Zeng Q, et al.(June 2006). "Hypoglycemic activity of
polysaccharide, with antioxidation, isolated from cultured
Cordyceps mycelia". Phytomedicine 13(6):
428–433. doi:10.1016/j.phymed.2005.02.002. PMID 16716913.
- ^ Winkler, Daniel (2008). "Yarsa Gunbu (Cordyceps
sinensis) and the Fungal Commodification of the Rural Economy in
Nepal". Economic
Botany 62 (3): 291–305. doi:10.1007/s12231-008-9038-3 (inactive
2010-01-07).
- ^[http://www.ctvbc.ctv.ca/servlet/an/local/CTVNews/20100714/bc_herbal_robbery_100714/20100714?hub=BritishColumbiaHome "Bird's nests, fungus stolen in high-end
B.C. heist."
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